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Both drugs showed limited benefit. Only half of the participants TM ulcers had healed by 6 months. For those with healed ulcers, recurrence was common (30%). Decellularised mammalian extracellular matrices (ECM) have been widely accepted as an ideal substrate for repair and remodelling of numerous tissues in clinical and pre clinical studies. Recent studies have demonstrated the ability of ECM scaffolds derived from site specific homologous tissues to direct cell differentiation. The present study investigated the suitability of hydrogels derived from different source tissues: bone, spinal cord and dentine, as suitable carriers to deliver human apical papilla derived mesenchymal stem cells (SCAP) for spinal cord regeneration.