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Multivariable analysis was performed to assess the association between PPT and DAS28 components, DAS28 P (the proportion of DAS28 derived from the patient reported components of visual analogue score and tender joint count), or fibromyalgia status.RESULTS: More sensitive PPTs at sites over or distant from joints were each associated with greater reported pain, higher patient reported DAS28 components, and poorer mental health. A high proportion of participants (48%) satisfied classification criteria for fibromyalgia, and fibromyalgia classification or characteristics were each associated with more sensitive PPTs, higher patient reported DAS28 components, and poorer mental health.CONCLUSIONS: Widespread sensitivity to pressure induced pain, a high prevalence of fibromyalgic features, higher patient reported DAS28 components, and poorer mental health are all linked in established RA. The increased sensitivity at nonjoint sites (sternum and anterior tibia), as well as over joints, indicates that central mechanisms may contribute to pain sensitivity in RA.

We found this hotel online and decided to book a room. I booked the room on one of those hotel booking sites. By mistake I clicked on the wrong date and didn’t realize it. Even with frequent applications of sunscreen, the millions of people now enjoying their summer outdoors may be putting themselves at increased risk of melanoma, the most serious skin cancer.Some visible light, as well as a wide range of ultraviolet (UV) light, may fuel a series of changes in skin cells, leading to melanoma, says Richard B.He and his collegues use specially bred fish to study the effects of different types of light on cells that contain melanin, the skin pigment that colors moles brown. These studies have provided concrete evidence that not only UV B the rays with wavelengths between 280 and 320 nanometers that cause sunburn but also light with longer wavelengths can induce cancer, says Setlow.The fish are a cross between a swordtail and a hybrid of a swordtail and the platyfish, two popular tropical aquarium pets. When young, these heavily pigmented fish fit easily into the thimble size glass tube of a spectrometer, which provides light of single wavelengths, and develop tumors after just one exposure to this light, Setlow explains.

Horse racing was more mainstream back then. Horses like Ruffian did not need social media to catapult them to stardom. The Sport of Kings was covered by most newspapers and sporting magazines, and Ruffian was its new star, and she was a girl. We extend current knowledge on new venture legitimation by focusing on how environmental entrepreneurs enact their values and beliefs during the legitimation process and on the resultant business and personal consequences. On the basis of our longitudinal analysis of six cases studies we develop a staged process model of legitimation. Our findings suggest three novel insights.

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