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In addition to slow functional kinetics, C26 displayed high affinity with extremely slow receptor dissociation kinetics, giving a receptor residence half life of 32.7 minutes at 37C, which represents the slowest dissociation rate we have observed for any 2 adrenoceptor agonist tested to date. In conclusion, we propose that the gradual accumulation of long lived active receptor complexes contributes to the increased intrinsic activity of C26 over time. This highlights the need to consider the temporal aspects of agonist binding and signaling when characterizing ligands as super agonists..
The evening was a transformative experience. The melodic sounds the otherworldly sounds the cacophonous sounds fed my soul and spirit. It was like a musical three ringed circus on the planet Venus with Sun Ra being the ring master conducting the proceedings with a wave of his hand, the bend of a finger, the movement of his cape as John Gilmore unleashed a sonorous gut wrenching barrage of cascading notes.
This cloud collapsed under gravity. As it collapsed, it started spinning more quickly and began to flatten to conserve angular momentum. Laplace also proposed that planets were formed by the condensation of annular rings around the Sun which was one of the major drawbacks of this theory..
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